Image button cell biology and subcellular localization
Orange image button Ohnishi S, Vanderheyden JL, Tanaka E, Patel B, De Grand AM, Laurence RG, Yamashita K, Frangioni JV. Intraoperative detection of cell injury and cell death with an 800 nm near-infrared fluorescent annexin V derivative. Am J Transplant.
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Orange image button Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME, Yaffe MB. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol. .
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Orange image button Hausdorff SF, Frangioni JV, Birnbaum MJ. Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes. J Biol Chem. .
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Orange image button Frangioni JV, Moghal N, Stuart-Tilley A, Neel BG, Alper SL. The DNA binding domain of retinoic acid receptor beta is required for ligand-dependent suppression of proliferation. Application of general purpose mammalian coexpression vectors. J Cell Sci. .
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Frangioni JV, Neel BG. Use of a general purpose mammalian expression vector for studying intracellular protein targeting: identification of critical residues in the nuclear lamin A/C nuclear localization signal. J Cell Sci. .
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Frangioni JV, Oda A, Smith M, Salzman EW, Neel BG. Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets. EMBO J. .
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Frangioni JV, Beahm PH, Shifrin V, Jost CA, Neel BG. The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. Cell .
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Gebert JF, Moghal N, Frangioni JV, Sugarbaker DJ, Neel BG. High frequency of retinoic acid receptor beta abnormalities in human lung cancer. Oncogene .
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Schwartz MA, Rupp EE, Frangioni JV, Lechene CP. Cytoplasmic pH and anchorage-independent growth induced by v-Ki-ras, v-src or polyoma middle T. Oncogene .
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Ingber DE, Prusty D, Frangioni JV, Cragoe EJ, Jr., Lechene C, Schwartz MA. Control of intracellular pH and growth by fibronectin in capillary endothelial cells. J Cell Biol. .
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  Image button for ligand discovery and multimerization
Orange image button Humblet V, Misra P, Frangioni JV. An HPLC/Mass spectrometry platform for the development of multimodality contrast agents and targeted therapeutics: Prostate-specific membrane antigen small molecule derivatives. Contrast Med Mol Imag. 2006; in press.
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Orange image button Ohnishi S, Vanderheyden JL, Tanaka E, Patel B, De Grand AM, Laurence RG, Yamashita K, Frangioni JV. Intraoperative detection of cell injury and cell death with an 800 nm near-infrared fluorescent annexin V derivative. Am J Transplant.
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Orange image button Humblet V, Lapidus R, Williams LR, Tsukamoto T, Rojas C, Majer P, Hin B, Ohnishi S, De Grand AM, Zaheer A, Renze JT, Nakayama A, Slusher BS, Frangioni JV. High affinity near-infrared fluorescent small molecule contrast agents for in vivo imaging of prostate-specific membrane antigen. Mol Imaging
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Orange image button Romeo G, Frangioni JV, Kazlauskas A. Profilin acts downstream of LDL to mediate diabetic endothelial cell dysfunction. Faseb J. .
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Orange image button Maison W, Frangioni JV, Pannier N. Synthesis of rigid multivalent scaffolds based on adamantane. Org Lett. .
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Orange image button Maison W, Frangioni JV. Improved chemical strategies for the targeted therapy of cancer. Angew Chem Int Ed Engl. .
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Orange image button Lenkinski RE, Ahmed M, Zaheer A, Frangioni JV, Goldberg SN. Near-infrared fluorescence imaging of microcalcification in an animal model of breast cancer. Acad Radiol. .
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Orange image button Zaheer A, Lenkinski RE, Mahmood A, Jones AG, Cantley LC, Frangioni JV. In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat Biotechnol. .
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  Image button for magnetic resonance imaging and contrast agents
Orange image button Humblet V, Misra P, Frangioni JV. An HPLC/Mass spectrometry platform for the development of multimodality contrast agents and targeted therapeutics: Prostate-specific membrane antigen small molecule derivatives. Contrast Med Mol Imag. 2006; in press.
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Orange image button Alves FC, Donato P, Sherry AD, Zaheer A, Zhang S, Lubag AJ, Merritt ME, Lenkinski RE, Frangioni JV, Neves M and others. Silencing of phosphonate-gadolinium magnetic resonance imaging contrast by hydroxyapatite binding. Invest Radiol. .
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  Image button for molecular biology, phage display, and protein expression systems
Orange image button Romeo G, Frangioni JV, Kazlauskas A. Profilin acts downstream of LDL to mediate diabetic endothelial cell dysfunction. Faseb J. .
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Orange image button Cowley SM, Kang RS, Frangioni JV, Yada JJ, DeGrand AM, Radhakrishnan I, Eisenman RN. Functional analysis of the Mad1-mSin3A repressor-corepressor interaction reveals determinants of specificity, affinity, and transcriptional response. Mol Cell Biol. .
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Orange image button Voss SD, De Grand AM, Romeo GR, Cantley LC, Frangioni JV. An integrated vector system for cellular studies of phage display-derived peptides. Anal Biochem. .
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Orange image button Frangioni JV, LaRiccia LM, Cantley LC, Montminy MR. Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening. Nat Biotechnol. .
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Orange image button Frangioni JV, Moghal N, Stuart-Tilley A, Neel BG, Alper SL. The DNA binding domain of retinoic acid receptor beta is required for ligand-dependent suppression of proliferation. Application of general purpose mammalian coexpression vectors. J Cell Sci. .
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Orange image button Frangioni JV, Neel BG. Use of a general purpose mammalian expression vector for studying intracellular protein targeting: identification of critical residues in the nuclear lamin A/C nuclear localization signal. J Cell Sci. .
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Orange image button Frangioni JV, Oda A, Smith M, Salzman EW, Neel BG. Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets. EMBO J. .
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Orange image button Frangioni JV, Neel BG. Solubilization and purification of enzymatically active glutatdione S-transferase (pGEX) fusion proteins. Anal Biochem. .
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Orange image button Frangioni JV, Beahm PH, Shifrin V, Jost CA, Neel BG. The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. Cell .
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  Image button for NIR fluorescent sentinel lymph node mapping
Orange image button Parungo CP, Soybel DI, Colson YL, Kim S-W, Ohnishi S, De Grand AM, Laurence RG, Soltesz EG, Chen FY, Cohn LH, Bawendi MG, Frangioni JV. Lymphatic drainage of the peritoneal space: A pattern dependent on bowel lymphatics. Ann Surg Onc. 2006; in press.
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Orange image button Tanaka E, Choi HS, Fujii H, Bawendi MG, Frangioni JV. Image-guided oncologic surgery using invisible light: Completed pre-clinical development for sentinel lymph node mapping. Ann Surg Onc. 2006; [].
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Soltesz EG, Kim S, Kim SW, Laurence RG, De Grand AM, Parungo CP, Cohn LH, Bawendi MG, Frangioni JV. Sentinel lymph node mapping of the gastrointestinal tract by using invisible light. Ann Surg Oncol.
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Soltesz EG, Kim S, Laurence RG, DeGrand AM, Parungo CP, Dor DM, Cohn LH, Bawendi MG, Frangioni JV, Mihaljevic T. Intraoperative sentinel lymph node mapping of the lung using near-infrared fluorescent quantum dots. Ann Thorac Surg. ; discussion 269-77.
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Orange image button Parungo CP, Ohnishi S, Kim SW, Kim S, Laurence RG, Soltesz EG, Chen FY, Colson YL, Cohn LH, Bawendi MG and otders. Intraoperative identification of esophageal sentinel lymph nodes with near-infrared fluorescence imaging. J Thorac Cardiovasc Surg. .
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Orange image button Parungo CP, Colson YL, Kim SW, Kim S, Cohn LH, Bawendi MG, Frangioni JV. Sentinel lymph node mapping of the pleural space. Chest. .
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Orange image button Ohnishi S, Lomnes SJ, Laurence RG, Gogbashian A, Mariani G, Frangioni JV. Organic alternatives to quantum dots for intraoperative near-infrared fluorescent sentinel lymph node mapping. Mol Imaging. .
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Orange image button Kim SW, Zimmer JP, Ohnishi S, Tracy JB, Frangioni JV, Bawendi MG. Engineering InAs(x)P(1-x)/InP/ZnSe III-V alloyed core/shell quantum dots for the near-infrared. J Am Chem Soc.
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Parungo CP, Ohnishi S, De Grand AM, Laurence RG, Soltesz EG, Colson YL, Kang PM, Mihaljevic T, Cohn LH, Frangioni JV. In vivo optical imaging of pleural space drainage to lymph nodes of prognostic significance. Ann Surg Oncol. .
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Orange image button Kim S, Lim YT, Soltesz EG, De Grand AM, Lee J, Nakayama A, Parker JA, Mihaljevic T, Laurence RG, Dor DM and others. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat Biotechnol. .
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  Image button for NIR fluorescent (non-quantum dot) contrast agents
Orange image button Ohnishi S, Garfein ES, Karp SJ, Frangioni JV. Radiolabeled and near-infrared fluorescent fibrinogen derivatives create a system for the identification and repair of obscure gastrointestinal bleeding. Surgery. 2006; in press.
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Orange image button Flaumenhaft R, Tanaka E, Graham GJ, De Grand AM, Laurence RG, Hoshino K, Hajjar RJ, Frangioni JV. Localization and quantification of platelet-rich thrombi in large blood vessels using near-infrared fluorescence imaging. Circulation. 2006: in press.
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Orange image button Tanaka E, Choi HS, Fujii H, Bawendi MG, Frangioni JV. Image-guided oncologic surgery using invisible light: Completed pre-clinical development for sentinel lymph node mapping. Ann Surg Onc. 2006; [].
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Orange image button Zaheer A, Murshed M, De Grand AM, Morgan TG, Karsenty G, Frangioni JV. Optical imaging ofhHydroxyapatite in the calcified vasculature of transgenic animals. Arterioscler Thromb Vasc Biol.
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Orange image button Ohnishi S, Vanderheyden JL, Tanaka E, Patel B, De Grand AM, Laurence RG, Yamashita K, Frangioni JV. Intraoperative detection of cell injury and cell death with an 800 nm near-infrared fluorescent annexin V derivative. Am J Transplant. .
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Orange image button Hoshino K, Kimura T, De Grand AM, Yoneyama R, Kawase Y, Houser S, Ly HQ, Kushibiki T, Furukawa Y, Ono K, Tabata Y, Frangioni JV, Kita T, Hajjar RJ, Hayase M. Three catheter-based strategies for cardiac delivery of therapeutic gelatin microspheres.Gene Ther. .
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Orange image button Parungo CP, Ohnishi S, Kim SW, Kim S, Laurence RG, Soltesz EG, Chen FY, Colson YL, Cohn LH, Bawendi MG and otders. Intraoperative identification of esophageal sentinel lymph nodes with near-infrared fluorescence imaging. J Thorac Cardiovasc Surg. .
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Orange image button Ohnishi S, Lomnes SJ, Laurence RG, Gogbashian A, Mariani G, Frangioni JV. Organic alternatives to quantum dots for intraoperative near-infrared fluorescent sentinel lymph node mapping. Mol Imaging. .
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Orange image button Humblet V, Lapidus R, Williams LR, Tsukamoto T, Rojas C, Majer P, Hin B, Ohnishi S, De Grand AM, Zaheer A, Renze JT, Nakayama A, Slusher BS, Frangioni JV. High affinity near-infrared fluorescent small molecule contrast agents for in vivo imaging of prostate-specific membrane antigen. Mol Imaging
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Orange image button Parungo CP, Ohnishi S, De Grand AM, Laurence RG, Soltesz EG, Colson YL, Kang PM, Mihaljevic T, Cohn LH, Frangioni JV. In vivo optical imaging of pleural space drainage to lymph nodes of prognostic significance. Ann Surg Oncol. .
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Orange image button Nakayama A, Bianco AC, Zhang CY, Lowell BB, Frangioni JV. Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging. Mol Imaging .
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Orange image button Lenkinski RE, Ahmed M, Zaheer A, Frangioni JV, Goldberg SN. Near-infrared fluorescence imaging of microcalcification in an animal model of breast cancer. Acad Radiol. .
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Orange image button Frangioni JV. In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol. .
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Orange image button Zaheer A, Wheat TE, Frangioni JV. IRDye78 conjugates for near-infrared fluorescence imaging. Mol Imaging .
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Orange image button Nakayama A, del Monte F, Hajjar RJ, Frangioni JV. Functional near-infrared fluorescence imaging for cardiac surgery and targeted gene therapy. Mol Imaging .
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Orange image button Zaheer A, Lenkinski RE, Mahmood A, Jones AG, Cantley LC, Frangioni JV. In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat Biotechnol. .
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  Image button for NIR fluorescent quantum dot contrast agents
Orange image button Parungo CP, Soybel DI, Colson YL, Kim S-W, Ohnishi S, De Grand AM, Laurence RG, Soltesz EG, Chen FY, Cohn LH, Bawendi MG, Frangioni JV. Lymphatic drainage of the peritoneal space: A pattern dependent on bowel lymphatics. Ann Surg Onc. 2006; in press.
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Orange image button Tanaka E, Choi HS, Fujii H, Bawendi MG, Frangioni JV. Image-guided oncologic surgery using invisible light: Completed pre-clinical development for sentinel lymph node mapping. Ann Surg Onc. 2006; [].
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Orange image button Soltesz EG, Kim S, Kim SW, Laurence RG, De Grand AM, Parungo CP, Cohn LH, Bawendi MG, Frangioni JV. Sentinel lymph node mapping of the gastrointestinal tract by using invisible light. Ann Surg Oncol.
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Orange image button Zimmer JP, Kim SW, Ohnishi S, Tanaka E, Frangioni JV, Bawendi MG. Size series of small indium arsenide-zinc selenide core-shell nanocrystals and their application to in vivo imaging. J Am Chem Soc.
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Orange image button Frangioni JV. Self-illuminating quantum dots light the way. Nat Biotechnol.
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Orange image button Soltesz EG, Kim S, Laurence RG, DeGrand AM, Parungo CP, Dor DM, Cohn LH, Bawendi MG, Frangioni JV, Mihaljevic T. Intraoperative sentinel lymph node mapping of the lung using near-infrared fluorescent quantum dots. Ann Thorac Surg. ; discussion 269-77.
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Orange image button Parungo CP, Ohnishi S, Kim SW, Kim S, Laurence RG, Soltesz EG, Chen FY, Colson YL, Cohn LH, Bawendi MG and otders. Intraoperative identification of esophageal sentinel lymph nodes with near-infrared fluorescence imaging. J Thorac Cardiovasc Surg. .
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Orange image button Parungo CP, Colson YL, Kim SW, Kim S, Cohn LH, Bawendi MG, Frangioni JV. Sentinel lymph node mapping of the pleural space. Chest. .
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Orange image button Kim SW, Zimmer JP, Ohnishi S, Tracy JB, Frangioni JV, Bawendi MG. Engineering InAs(x)P(1-x)/InP/ZnSe III-V alloyed core/shell quantum dots for the near-infrared. J Am Chem Soc.
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Orange image button Kim S, Lim YT, Soltesz EG, De Grand AM, Lee J, Nakayama A, Parker JA, Mihaljevic T, Laurence RG, Dor DM and others. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat Biotechnol. .
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Orange image button Lim YT, Kim S, Nakayama A, Stott NE, Bawendi MG, Frangioni JV. Selection of quantum dot wavelengths for biomedical assays and imaging. Mol Imaging. .
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Orange image button Frangioni JV. In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol. .
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  Image button for NIR fluorescence imaging systems and calibration
Orange image button Parungo CP, Soybel DI, Colson YL, Kim S-W, Ohnishi S, De Grand AM, Laurence RG, Soltesz EG, Chen FY, Cohn LH, Bawendi MG, Frangioni JV. Lymphatic drainage of the peritoneal space: A pattern dependent on bowel lymphatics. Ann Surg Onc. 2006; in press.
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Orange image button Tanaka E, Choi HS, Fujii H, Bawendi MG, Frangioni JV. Image-guided oncologic surgery using invisible light: Completed pre-clinical development for sentinel lymph node mapping. Ann Surg Onc. 2006; [].
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Orange image button De Grand AM, Lomnes SJ, Lee DS, Pietrzykowski M, Ohnishi S, Morgan TG, Gogbashian A, Laurence RG, Frangioni JV. Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons. J Biomed Opt.
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Orange image button Gioux S, De Grand AM, Lee DS, Yazdanfarc S, Idoine JD, Lomnes SJ, Frangioni JV. Improved optical sub-systems for intraoperative near-infrared fluorescence imaging. In: Analoui M, Dunn DA, editors. Proceedings of SPIE (International Society for Optical Imaging). Optical Methods in Drug Discovery and Development Volume 6009; 2005; Oct 23-26; Boston, MA. Bellingham, WA; 2005. p.39-48.
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Orange image button Nakayama A, Bianco AC, Zhang CY, Lowell BB, Frangioni JV. Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging. Mol Imaging .
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Orange image button De Grand AM, Frangioni JV. An operational near-infrared fluorescence imaging system prototype for large animal surgery. Technol Cancer Res Treat. .
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Orange image button Nakayama A, del Monte F, Hajjar RJ, Frangioni JV. Functional near-infrared fluorescence imaging for cardiac surgery and targeted gene therapy. Mol Imaging .
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Orange image button Zaheer A, Lenkinski RE, Mahmood A, Jones AG, Cantley LC, Frangioni JV. In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat Biotechnol. .
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  Image button for radioscintigraphic imagings systems and calibration
Orange image button English JR, Accorsi R, Idoine JD, Parker JA, Renze JT, Lanza RC, Frangioni JV. Sub-millimeter technetium-99m calibration sources. Mol Imaging Biol. .
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  Image button for reviews and perspectives
Orange image button Frangioni JV. Translating in vivo diagnostics into clinical reality. Nat Biotechnol. . No abstract available
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Orange image button Chemaly ER, Yoneyama R, Frangioni JV, Hajjar RJ. Tracking stem cells in the cardiovascular system. Trends Cardiovasc Med .
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Orange image button Frangioni JV, Hajjar RJ. In vivo tracking of stem cells for clinical trials in cardiovascular disease. Circulation .
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Orange image button Maison W, Frangioni JV. Improved chemical strategies for the targeted therapy of cancer. Angew Chem Int Ed Engl. .
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Orange image button Frangioni JV. In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol. .
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  Image button for stem cells and gene therapy
Orange image button Hoshino K, Kimura T, De Grand AM, Yoneyama R, Kawase Y, Houser S, Ly HQ, Kushibiki T, Furukawa Y, Ono K, Tabata Y, Frangioni JV, Kita T, Hajjar RJ, Hayase M. Three catheter-based strategies for cardiac delivery of therapeutic gelatin microspheres.Gene Ther. 2006 May 18; .
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Orange image button Hayase M, Del Monte F, Kawase Y, Macneill BD, McGregor J, Yoneyama R, Hoshino K, Tsuji T, De Grand AM, Gwathmey JK and others. Catheter-based antegrade intracoronary viral gene delivery with coronary venous blockade. Am J Physiol Heart Circ Physiol. .
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Orange image button Chemaly ER, Yoneyama R, Frangioni JV, Hajjar RJ. Tracking stem cells in the cardiovascular system. Trends Cardiovasc Med .
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Orange image button Frangioni JV, Hajjar RJ. In vivo tracking of stem cells for clinical trials in cardiovascular disease. Circulation .
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Orange image button Humblet V, Misra P, Frangioni JV. An HPLC/Mass spectrometry platform for the development of multimodality contrast agents and targeted therapeutics: Prostate-specific membrane antigen small molecule derivatives. Contrast Med Mol Imag. 2006; in press.
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Orange image button Ohnishi S, Garfein ES, Karp SJ, Frangioni JV. Radiolabeled and near-infrared fluorescent fibrinogen derivatives create a system for the identification and repair of obscure gastrointestinal bleeding. Surgery. 2006; in press.
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